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Medications that inhibit CYP2D6 action, like paroxetine and quinidine, may lead to reduced clearance of oxycodone which may lead to a rise in oxycodone plasma concentrations. Concurrent administration of quinidine resulted in a rise in oxycodone Cmax by 11%, AUC by thirteen%, and t½ elim.Examine the Medication Guide furnished by your pharmacist be